In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19.

ABSTRACT:

Background

Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripheral arterial tonometry (PAT).

Methods

This is a prospective, observational, case-control and blinded study. The population was comprised by 3 groups: patients investigated during acute COVID-19 (group 1), patients investigated during past COVID-19 (group 2), and controls 1:1 matched to COVID-19 patients by demographics and cardiovascular risk factors (group 3). The natural logarithmic scaled reactive hyperemia index (LnRHI), a measure of endothelium-mediated dilation of

SUBMITTER: Mejia-Renteria H 

PROVIDER: S-EPMC8542397 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature