Reasons for Discontinuing Active Surveillance: Assessment of 21 Centres in 12 Countries in the Movember GAP3 Consortium.

ABSTRACT:

Background

Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa).

Objective

Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation.

Design, setting, and participants

We compared data from 10296 men on AS from 21 centres across 12 countries.

Outcome measurements and statistical analysis

Cumulative incidence methods were used to estimate the cumulative incidence rates of AS discontinuation.

Results and limitations

During 5-yr follow-up, 27.5% (95% confidence interval [CI]: 26.4-28.6%) men showed signs of disease progression, 12.8% (95% CI: 12.0-13.6%) converted to active treatment without eviden

SUBMITTER: Van Hemelrijck M 

PROVIDER: S-EPMC8542419 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature