Design and validation of a modular micro-robotic system for the mechanical characterization of soft tissues.

ABSTRACT: The mechanical properties of tissues are critical design parameters for biomaterials and regenerative therapies seeking to restore functionality after disease or injury. Characterizing the mechanical properties of native tissues and extracellular matrix throughout embryonic development helps us understand the microenvironments that promote growth and remodeling, activities critical for biomaterials to support. The mechanical characterization of small, soft materials like the embryonic tissues of the mouse, an established mammalian model for development, is challenging due to difficulties in handling minute geometries and resolving forces of low magnitude. While uniaxial tensile testing is the physiologically relevant modality to characterize tissues that are loaded in tension in vivo, ther

SUBMITTER: Acuna A 

PROVIDER: S-EPMC8542608 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature