Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.

ABSTRACT: Dendritic spine dynamics are thought to be substrates for motor learning and memory, and altered spine dynamics often lead to impaired performance. Here, we describe an exception to this rule by studying mice lacking paired immunoglobulin receptor B (PirB^-/-). Pyramidal neuron dendrites in PirB^-/- mice have increased spine formation rates and density. Surprisingly, PirB^-/- mice learn a skilled reaching task faster than wild-type (WT) littermates. Furthermore, stabilization of learning-induced spines is elevated in PirB^-/- mice. Mechanistically, single-spine uncaging experiments suggest that PirB is required for NMDA receptor (NMDAR)-dependent spine shrinkage. The degree of survival of newly formed spines correlates with performance, suggesting th

SUBMITTER: Albarran E 

PROVIDER: S-EPMC8542616 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature