Psilocybin for End-of-Life Anxiety Symptoms: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

To systematically examine the effectiveness and tolerability of psilocybin for treating end-of-life anxiety symptoms.

Methods

The Medline, Embase, CENTRAL, and PsycINFO databases were searched up to November 25, 2020. We enrolled clinical trials investigating psilocybin for treating end-of-life anxiety symptoms. Meta-analysis was conducted using random-effects model.

Results

Overall, five studies were included, revealing that psilocybin was superior to the placebo in treating state anxiety at 1 day (Hedges' g, -0.70; 95% confidence interval, -1.01 to -0.39) and 2 weeks (-1.03; -1.47 to -0.60) after treatment. Psilocybin was more effective than placebo in treating trait anxiety at 1 day (-0.71; -1.15 to -0.26), 2 weeks (-1.08; -1.80 to -0.36), and 6 months (-

SUBMITTER: Yu CL 

PROVIDER: S-EPMC8542741 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature