Alterations in the Occipital Cortex of Drug-Naive Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness.

ABSTRACT:

Objective

Advances in surface-based morphometric methods have allowed researchers to separate cortical volume into cortical thickness (CTh) and surface area (SA). Although CTh alterations in major depressive disorder (MDD) have been observed in numerous studies, few studies have described significant SA alterations. Our study aimed to measure patients' SAs and to compare it with their CTh to examine whether SA exhibits alteration patterns that differ from those of CTh in drug-naïve patients with MDD.

Methods

A total of 71 drug-naïve MDD patients and 111 healthy controls underwent structural magnetic resonance imaging, and SA and CTh were analyzed between the groups.

Results

We found a smaller SA in the left superior occipital gyrus (L-SOG) in drug-naïve patients with

SUBMITTER: Lee JS 

PROVIDER: S-EPMC8542746 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature