Structural and Evolutionary Insights Into the Binding of Host Receptors by the Rabies Virus Glycoprotein.

ABSTRACT: Rabies represents a typical model for spillover of zoonotic viral diseases among multiple hosts. Understanding the success of rabies virus (RV) in switching hosts requires the analysis of viral evolution and host interactions. In this study, we have investigated the structural and sequence analysis of host receptors among different RV susceptible host species. Our extensive bioinformatic analysis revealed the absence of the integrin plexin domain in the integrin β1 (ITGB1) receptor of the black fruit bats in the current annotation of the genome. Interestingly, the nicotinic acetyl choline receptor (nAChR) interaction site with the glycoprotein (G) of RV was conserved among different species. To study the interaction dynamics between RV-G protein and the RV receptors, we constructed and ana

SUBMITTER: Khalifa ME 

PROVIDER: S-EPMC8542875 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature