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Low-pathogenicity influenza viruses replicate differently in laughing gulls and mallards.


ABSTRACT: Wild aquatic birds are natural reservoirs of low-pathogenicity avian influenza viruses (LPAIVs). Laughing gulls inoculated with four gull-origin LPAIVs (H7N3, H6N4, H3N8, and H2N3) had a predominate respiratory infection. By contrast, mallards inoculated with two mallard-origin LPAIVs (H5N6 and H4N8) became infected and had similar virus titers in oropharyngeal (OP) and cloacal (CL) swabs. The trend toward predominate OP shedding in gulls suggest a greater role of direct bird transmission in maintenance, whereas mallards shedding suggests importance of fecal-oral transmission through water contamination. Additional infectivity and pathogenesis studies are needed to confirm this replication difference for LPAI viruses in gulls.

SUBMITTER: Criado MF 

PROVIDER: S-EPMC8542958 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Low-pathogenicity influenza viruses replicate differently in laughing gulls and mallards.

Criado Miria F MF   Moresco Kira A KA   Stallknecht David E DE   Swayne David E DE  

Influenza and other respiratory viruses 20210610 6


Wild aquatic birds are natural reservoirs of low-pathogenicity avian influenza viruses (LPAIVs). Laughing gulls inoculated with four gull-origin LPAIVs (H7N3, H6N4, H3N8, and H2N3) had a predominate respiratory infection. By contrast, mallards inoculated with two mallard-origin LPAIVs (H5N6 and H4N8) became infected and had similar virus titers in oropharyngeal (OP) and cloacal (CL) swabs. The trend toward predominate OP shedding in gulls suggest a greater role of direct bird transmission in mai  ...[more]

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