SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI.

ABSTRACT: This work introduces a compartment-based model for apparent cell body (namely soma) and neurite density imaging (SANDI) using non-invasive diffusion-weighted MRI (DW-MRI). The existing conjecture in brain microstructure imaging through DW-MRI presents water diffusion in white (WM) and gray (GM) matter as restricted diffusion in neurites, modelled by infinite cylinders of null radius embedded in the hindered extra-neurite water. The extra-neurite pool in WM corresponds to water in the extra-axonal space, but in GM it combines water in the extra-cellular space with water in soma. While several studies showed that this microstructure model successfully describe DW-MRI data in WM and GM at b ​≤ ​3,000 ​s/mm² (or 3 ​ms/μm²), it has been also shown to fail in GM at high b v

SUBMITTER: Palombo M 

PROVIDER: S-EPMC8543044 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature