Neurodevelopmental outcome of patients with congenital gastrointestinal malformations: a systematic review and meta-analysis.

ABSTRACT:

Aim

Children with congenital gastrointestinal malformations may be at risk of neurodevelopmental impairment due to challenges to the developing brain, including perioperative haemodynamic changes, exposure to anaesthetics and postoperative inflammatory influences. This study aggregates existing evidence on neurodevelopmental outcome in these patients using meta-analysis.

Method

PubMed, Embase and Web of Science were searched for peer-reviewed articles published until October 2019. Out of the 5316 unique articles that were identified, 47 studies met the inclusion criteria and were included. Standardised mean differences (Cohen's d) between cognitive, motor and language outcome of patients with congenital gastrointestinal malformations and normative data (39 studies) or the st

SUBMITTER: Roorda D 

PROVIDER: S-EPMC8543204 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature