Growth Factor Therapy for Parkinson's Disease: Alternative Delivery Systems.

ABSTRACT: Despite decades of research and billions in global investment, there remains no preventative or curative treatment for any neurodegenerative condition, including Parkinson's disease (PD). Arguably, the most promising approach for neuroprotection and neurorestoration in PD is using growth factors which can promote the growth and survival of degenerating neurons. However, although neurotrophin therapy may seem like the ideal approach for neurodegenerative disease, the use of growth factors as drugs presents major challenges because of their protein structure which creates serious hurdles related to accessing the brain and specific targeting of affected brain regions. To address these challenges, several different delivery systems have been developed, and two major approaches-direct infusion

SUBMITTER: Jarrin S 

PROVIDER: S-EPMC8543245 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature