A Comprehensive Review: Molecular and Genetic Background of Indirect Inguinal Hernias.

ABSTRACT:

Background

The occurrence of indirect inguinal hernias (IIH) is 5 times more prevalent than that of direct inguinal hernias (IH) and it is 7 times more common in males, owing to the attendance of the processus vaginalis (PV) throughout testicular descent.

Summary

In children, the immense mainstream of IH is indirect. The progress of IIH development in children is instigated with a patent PV, which is mostly treated by simple herniorrhaphy. Syndromes of the collagen, microfibril, elastin, and glycosaminoglycan constituents of the extracellular matrix may attend to the development of IH. Our recent research showed that the lack of epithelial-mesenchymal transition (EMT) in children contributes to the development of IIH, while the scenario is defined as the opposite in adults.

SUBMITTER: Somuncu S 

PROVIDER: S-EPMC8543302 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature