Association of serum neurofilament light chain levels and neuropsychiatric manifestations in systemic lupus erythematosus.

ABSTRACT:

Background

The aim was to evaluate the diagnostic potential of serum neurofilament light chain (sNfL) measurements in patients with neuropsychiatric systemic lupus erythematosus (NPSLE).

Methods

sNfL levels were determined by single molecule array assay in a retrospective cross-sectional cohort of 144 patients with systemic lupus erythematosus (SLE). After log-transformation of sNfL levels, mean sNfL levels were compared between NPSLE patients and SLE patients without neuropsychiatric disease using Student's t test. Furthermore, the association of different neuropsychiatric manifestations with sNfL levels was assessed using a one-way analysis of variance (ANOVA) with post hoc analysis. Associations of sNfL with clinical and laboratory parameters were assessed by corre

SUBMITTER: Engel S 

PROVIDER: S-EPMC8543555 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature