Multiatlas Calibration of Biophysical Brain Tumor Growth Models with Mass Effect.

ABSTRACT: We present a 3D fully-automatic method for the calibration of partial differential equation (PDE) models of glioblastoma (GBM) growth with "mass effect", the deformation of brain tissue due to the tumor. We quantify the mass effect, tumor proliferation, tumor migration, and the localized tumor initial condition from a single multiparameteric Magnetic Resonance Imaging (mpMRI) patient scan. The PDE is a reaction-advection-diffusion partial differential equation coupled with linear elasticity equations to capture mass effect. The single-scan calibration model is notoriously difficult because the precancerous (healthy) brain anatomy is unknown. To solve this inherently ill-posed and illconditioned optimization problem, we introduce a novel inversion s

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC8543732 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature