Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells.

ABSTRACT:

Background

Despite increased interest in mesenchymal stromal cell (MSC)-based cell therapies for acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and our understanding of the potential in vivo mechanisms of MSC actions in ARDS remains limited. ARDS is driven by an acute severe innate immune dysregulation, often characterised by inflammation, coagulation and cell injury. How this inflammatory microenvironment influences MSC functions remains to be determined.

Aim

The aim of this study was to comparatively assess how the inflammatory environment present in ARDS lungs versus the lung environment present in healthy volunteers alters MSC behaviour.

Methods

Clinical-grade human bone marrow-derived MSCs (hMSCs) we

SUBMITTER: Rolandsson Enes S 

PROVIDER: S-EPMC8543758 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature