Bioinformatics screening of biomarkers related to liver cancer.

ABSTRACT:

Background

Liver cancer is a common malignant tumor in China, with high mortality. Its occurrence and development were thoroughly studied by high-throughput expression microarray, which produced abundant data on gene expression, mRNA quantification and the clinical data of liver cancer. However, the hub genes, which can be served as biomarkers for diagnosis and treatment of early liver cancer, are not well screened.

Results

Here we present a new method for getting 6 key genes, aiming to diagnose and treat the early liver cancer. We firstly analyzed the different expression microarrays based on TCGA database, and a total of 1564 differentially expressed genes were obtained, of which 1400 were up-regulated and 164 were down-regulated. Furthermore, these differentially expresse

SUBMITTER: Wang YC 

PROVIDER: S-EPMC8543826 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature