Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease.

ABSTRACT:

Background

Dysbiosis of the gut microbiome is involved in the pathogenesis of various diseases, but the contribution of gut microbes to the progression of chronic obstructive pulmonary disease (COPD) is still poorly understood.

Methods

We carried out 16S rRNA gene sequencing and short-chain fatty acid analyses in stool samples from a cohort of 73 healthy controls, 67 patients with COPD of GOLD stages I and II severity, and 32 patients with COPD of GOLD stages III and IV severity. Fecal microbiota from the three groups were then inoculated into recipient mice for a total of 14 times in 28 days to induce pulmonary changes. Furthermore, fecal microbiota from the three groups were inoculated into mice exposed to smoke from biomass fuel to induce COPD-like changes.

Results

SUBMITTER: Li N 

PROVIDER: S-EPMC8543848 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature