Global connectivity in genome-scale metabolic networks revealed by comprehensive FBA-based pathway analysis.

ABSTRACT:

Background

Graph-based analysis (GBA) of genome-scale metabolic networks has revealed system-level structures such as the bow-tie connectivity that describes the overall mass flow in a network. However, many pathways obtained by GBA are biologically impossible, making it difficult to study how the global structures affect the biological functions of a network. New method that can calculate the biologically relevant pathways is desirable for structural analysis of metabolic networks.

Results

Here, we present a new method to determine the bow-tie connectivity structure by calculating possible pathways between any pairs of metabolites in the metabolic network using a flux balance analysis (FBA) approach to ensure that the obtained pathways are biologically relevant. We tested t

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8543872 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature