Tear miRNA expression analysis reveals miR-203 as a potential regulator of corneal epithelial cells.

ABSTRACT:

Background

microRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression. They are found within cells and in body fluids. Extracellular miRNAs have been shown to associate with the surrounding tissues. Therefore, we predicted that miRNAs in tears may contribute to regulate corneal epithelial cell function. However, information on the miRNA expression profile of tears is limited and the specific functions of tear miRNAs for corneal epithelial cells are still unknown. To study the role of tear miRNAs, we determined which miRNAs are highly expressed in tears and examined the involvement of miRNAs in corneal epithelial cell viability.

Methods

miRNAs extracted from monkey tears and sera were subjected to microarray analysis. miRNAs of which expression level

SUBMITTER: Nakagawa A 

PROVIDER: S-EPMC8543880 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature