Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need.

Results

We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope ¹⁷⁷Lu (¹⁷⁷Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. ¹⁷⁷Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), ¹⁷⁷Lu-SPN-GIP exhibited enhanced thera

SUBMITTER: Shi X 

PROVIDER: S-EPMC8543882 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature