Elevated expression of MKRN3 in squamous cell carcinoma of the head and neck and its clinical significance.

ABSTRACT:

Background

Squamous cell carcinoma of the head and neck (SCCHN) is one of the most common types of cancer that cause a substantial number of cancer-related deaths. Our previous study has revealed that makorin ring finger protein 3 (MKRN3) may act as a key regulator of the SCCHN tumorigenesis; however, its specific role in SCCHN progression has not been reported.

Methods

The Cancer Genome Atlas (TCGA) data analysis and quantitative polymerase chain reaction (qPCR) were used to quantify the MKRN3 mRNA expression levels in SCCHN; immunohistochemical staining or immunoblotting analyses were performed to detect MKRN3 protein expression. Kaplan-Meier plotter was used to assess the prognostic values of MKRN3 in terms of overall survival and disease-free survival. The expression dif

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8543891 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature