Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs.

ABSTRACT:

Background

The gut microbiota influences host performance playing a relevant role in homeostasis and function of the immune system. The aim of the present work was to identify microbial signatures linked to immunity traits and to characterize the contribution of host-genome and gut microbiota to the immunocompetence in healthy pigs.

Results

To achieve this goal, we undertook a combination of network, mixed model and microbial-wide association studies (MWAS) for 21 immunity traits and the relative abundance of gut bacterial communities in 389 pigs genotyped for 70K SNPs. The heritability (h²; proportion of phenotypic variance explained by the host genetics) and microbiability (m²; proportion of variance explained by the microbial composition) showed simi

SUBMITTER: Ramayo-Caldas Y 

PROVIDER: S-EPMC8543910 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature