Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.

ABSTRACT: Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer's disease (AD). To elucidate patterns of structural change in the MTL specifically associated with tau pathology, we compared high-resolution ex vivo MRI scans of human postmortem MTL specimens with histology-based pathological assessments of the MTL. MTL specimens were obtained from twenty-nine brain donors, including patients with AD, other dementias, and individuals with no known history of neurological disease. Ex vivo MRI scans were combined using a customized groupwise diffeomorphic registration approach to construct a 3D probabilistic atlas that captures the anatomical variability of the MTL. Using serial

SUBMITTER: Ravikumar S 

PROVIDER: S-EPMC8543911 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature