Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses.

ABSTRACT: Cranial base bones are formed through endochondral ossification. Synchondroses are growth plates located between cranial base bones that facilitate anterior-posterior growth of the skull. Coordinated proliferation and differentiation of chondrocytes in cranial base synchondroses is essential for cranial base bone growth. Herein, we report that constitutive activation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling via Tsc1 (Tuberous sclerosis 1) deletion in chondrocytes causes abnormal skull development with decreased size and rounded shape. In contrast to decreased anterior-posterior growth of the cranial base, mutant mice also exhibited significant expansion of cranial base synchondroses including the intersphenoid synchondrosis (ISS) and the spheno-occipital synchond

SUBMITTER: Hsieh YL 

PROVIDER: S-EPMC8543925 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature