Significance of CD8⁺ T cell infiltration-related biomarkers and the corresponding prediction model for the prognosis of kidney renal clear cell carcinoma.

ABSTRACT: Cytotoxic T cells expressing cell surface CD8 played a key role in anti-cancer immunotherapy, including kidney renal clear cell carcinoma (KIRC). Here we set out to comprehensively analyze and evaluate the significance of CD8⁺ T cell-related markers for patients with KIRC. We checked immune cell response in KIRC and identified cell type-specific markers and related pathways in the tumor-infiltrating CD8⁺ T (TIL-CD8T) cells. We used these markers to explore their prognostic signatures in TIL-CD8⁺ T by evaluating their prognostic efficacy and group differences at various levels. Through pan-cancer analysis, 12 of 63 up-regulated and 162 of 396 down-regulated genes in CD8+ T cells were found to be significantly correlated with the survival prognosis. Based on

SUBMITTER: Tian Y 

PROVIDER: S-EPMC8544304 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature