Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is characterized by rapid progression, high recurrence rate and poor prognosis. Early prediction for the prognosis and immunotherapy efficacy is of great significance to improve the survival of HCC patients. However, there is still no reliable predictor at present. This study is aimed to explore the role of centromere protein L (CENPL) in predicting prognosis and its association with immune infiltration in HCC.

Methods

The expression of CENPL was identified through analyzing the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data. The association between CENPL expression and clinicopathological features was investigated by the Wilcoxon signed-rank test or Kruskal Wallis test and logistic regression. The role of CENPL in

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC8544325 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature