Advances in Cardiac Development and Regeneration Using Zebrafish as a Model System for High-Throughput Research.

ABSTRACT: Heart disease is the leading cause of death in the United States and worldwide. Understanding the molecular mechanisms of cardiac development and regeneration will improve diagnostic and therapeutic interventions against heart disease. In this direction, zebrafish is an excellent model because several processes of zebrafish heart development are largely conserved in humans, and zebrafish has several advantages as a model organism. Zebrafish transcriptomic profiles undergo alterations during different stages of cardiac development and regeneration which are revealed by RNA-sequencing. ChIP-sequencing has detected genome-wide occupancy of histone post-translational modifications that epigenetically regulate gene expression and identified a locus with enhancer-like characteristics. ATAC-seque

SUBMITTER: Francoeur N 

PROVIDER: S-EPMC8544412 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature