Emerging Contributions of Solid-State NMR Spectroscopy to Chromatin Structural Biology.

ABSTRACT: The eukaryotic genome is packaged into chromatin, a polymer of DNA and histone proteins that regulates gene expression and the spatial organization of nuclear content. The repetitive character of chromatin is diversified into rich layers of complexity that encompass DNA sequence, histone variants and post-translational modifications. Subtle molecular changes in these variables can often lead to global chromatin rearrangements that dictate entire gene programs with far reaching implications for development and disease. Decades of structural biology advances have revealed the complex relationship between chromatin structure, dynamics, interactions, and gene expression. Here, we focus on the emerging contributions of magic-angle spinning solid-state nuclear magnetic resonance spectroscopy (MA

SUBMITTER: Ackermann BE 

PROVIDER: S-EPMC8544521 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature