Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke.

ABSTRACT:

Purpose

The current study aimed to investigate in an Armenian population the levels of pattern recognition molecules (PRMs) of lectin complement pathway (LCP), MBL (mannan-binding lectin) and M-ficolin in plasma in ischemic stroke (IS), and the possible association of 11 single nucleotide polymorphisms (SNPs) in MBL2, FCN1 and FCN2 genes.

Patients and methods

A total of 122 patients with IS and 150 control subjects were included in this study. Immunofluorometric assays (TRIFMAs) and real-time polymerase chain reactions with TaqMan probes were conducted.

Results

According to the results, the levels of M-ficolin in IS patients are significantly higher than in control subjects, and the MBL2 rs11003125 and rs12780112 SNPs, as well as MBL2

SUBMITTER: Tsakanova G 

PROVIDER: S-EPMC8544564 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature