Characterization of disease course and remission in early seropositive rheumatoid arthritis: results from the TACERA longitudinal cohort study.

ABSTRACT:

Background

To characterise disease course and remission in a longitudinal observational study of newly diagnosed, initially treatment-naïve patients with seropositive rheumatoid arthritis (RA).

Methods

Patients with early untreated seropositive RA were recruited from 28 UK centres. Multiple clinical and laboratory measures were collected every 3 months for up to 18 months. Disease activity was measured using the 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP) and Simplified Disease Activity Index (SDAI). Logistic regression models examined clinical predictors of 6-month remission and latent class mixed models characterised disease course.

Results

We enrolled 275 patients of whom 267 met full eligibility and provided baseline data. According to SDAI

SUBMITTER: RA-MAP Consortium 

PROVIDER: S-EPMC8544781 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature