Modular assembly of dynamic models in systems biology.

ABSTRACT: It is widely acknowledged that the construction of large-scale dynamic models in systems biology requires complex modelling problems to be broken up into more manageable pieces. To this end, both modelling and software frameworks are required to enable modular modelling. While there has been consistent progress in the development of software tools to enhance model reusability, there has been a relative lack of consideration for how underlying biophysical principles can be applied to this space. Bond graphs combine the aspects of both modularity and physics-based modelling. In this paper, we argue that bond graphs are compatible with recent developments in modularity and abstraction in systems biology, and are thus a desirable framework for constructing large-scale models. We use two exampl

SUBMITTER: Pan M 

PROVIDER: S-EPMC8544865 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature