Transcription Profiles Associated with Inducible Adhesion in Candida parapsilosis.

ABSTRACT: Candida parapsilosis has emerged as a frequent cause of invasive candidiasis with increasing evidence of unique biological features relative to C. albicans As it adapts to conditions within a mammalian host, rapid changes in gene expression are necessary to facilitate colonization and persistence in this environment. Adhesion of the organism to biological surfaces is a key first step in this process and is the focus of this study. Building on previous observations showing the importance of a member of the ALS gene family in C. parapsilosis adhesion, three clinical isolates were cultured under two conditions that mimic the mammalian host and promote adhesion, incubation at 37°C in tissue culture medium 199 or in human plasma. Transcriptional profiles using RNA-se

SUBMITTER: Bliss JM 

PROVIDER: S-EPMC8544891 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature