Glucan Unmasking Identifies Regulators of Temperature-Induced Translatome Reprogramming in C. neoformans.

ABSTRACT: The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major communicator to alert the cell to the changing environment. In response to stresses encountered in human hosts, pathogenic fungi remodel their cell walls. Masking the β-1,3-glucan component of the cell wall is critical to escape detection by innate immune cells. We previously demonstrated that β-1,3-glucan is unmasked in response to host temperature stress when translatome reprogramming is defective in Cryptococcus neoformans Here, we used β-1,3-glucan unmasking as an output to identify signaling modules involved both in masking and in translatome reprogramming in response to host temperature stress. We reveal that the high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pat

SUBMITTER: Bloom ALM 

PROVIDER: S-EPMC8544899 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature