Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition.

ABSTRACT:

Background

In addition to farming exposures in childhood, maternal farming exposures provide strong protection against allergic disease in their children; however, the effect of farming lifestyle on human milk (HM) composition is unknown.

Objective

This study aims to characterize the maternal immune effects of Old Order Mennonite (OOM) traditional farming lifestyle when compared with Rochester (ROC) families at higher risk for asthma and allergic diseases using HM as a proxy.

Methods

HM samples collected at median 2 months of lactation from 52 OOM and 29 ROC mothers were assayed for IgA₁ and IgA₂ antibodies, cytokines, endotoxin, HM oligosaccharides (HMOs), and targeted fatty acid (FA) metabolites. Development of early childhood atopic diseases i

SUBMITTER: Seppo AE 

PROVIDER: S-EPMC8545059 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature