Antibiotic-Selected Gene Amplification Heightens Metal Resistance.

ABSTRACT: The increasing frequency of antibiotic resistance poses myriad challenges to modern medicine. Environmental survival of multidrug-resistant bacteria in health care facilities, including hospitals, creates reservoirs for transmission of these difficult to treat pathogens. To prevent bacterial colonization, these facilities deploy an array of infection control measures, including bactericidal metals on surfaces, as well as implanted devices. Although antibiotics are routinely used in these health care environments, it is unknown whether and how antibiotic exposure affects metal resistance. We identified a multidrug-resistant Enterobacter clinical isolate that displayed heteroresistance to the antibiotic colistin, where only a minor fraction of cells within the population resist the dr

SUBMITTER: Hufnagel DA 

PROVIDER: S-EPMC8545094 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature