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GEInter: an R package for robust gene-environment interaction analysis.

ABSTRACT:

Summary

For understanding complex diseases, gene-environment (G-E) interactions have important implications beyond main G and E effects. Most of the existing analysis approaches and software packages cannot accommodate data contamination/long-tailed distribution. We develop GEInter, a comprehensive R package tailored to robust G-E interaction analysis. For both marginal and joint analysis, for data without and with missingness, for continuous and censored survival responses, it comprehensively conducts identification, estimation, visualization and prediction. It can fill an important gap in the existing literature and enjoy broad applicability.

Availability and implementation

TCGA data is analyzed as demonstrating examples. It is well known that such data is publicly available https://cran.r-project.org/web/packages/GEInter/.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Wu M

PROVIDER: S-EPMC8545291 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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GEInter: an R package for robust gene-environment interaction analysis.

Wu Mengyun M Qin Xing X Ma Shuangge S

Bioinformatics (Oxford, England) 20211001 20

<h4>Summary</h4>For understanding complex diseases, gene-environment (G-E) interactions have important implications beyond main G and E effects. Most of the existing analysis approaches and software packages cannot accommodate data contamination/long-tailed distribution. We develop GEInter, a comprehensive R package tailored to robust G-E interaction analysis. For both marginal and joint analysis, for data without and with missingness, for continuous and censored survival responses, it comprehen ...[more]

PMID: 33961050

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