Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection.

ABSTRACT: The dissemination of pathogens through blood and their establishment within organs lead to severe clinical outcomes. However, the within-host dynamics that underlie pathogen spread to and clearance from systemic organs remain largely uncharacterized. In animal models of infection, the observed pathogen population results from the combined contributions of bacterial replication, persistence, death, and dissemination, each of which can vary across organs. Quantifying the contribution of each these processes is required to interpret and understand experimental phenotypes. Here, we leveraged STAMPR, a new barcoding framework, to investigate the population dynamics of extraintestinal pathogenic Escherichia coli, a common cause of bacteremia, during murine systemic infection. We show that

SUBMITTER: Hullahalli K 

PROVIDER: S-EPMC8545400 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature