The accuracy of diagnostic indicators for coeliac disease: A systematic review and meta-analysis.

ABSTRACT:

Background

The prevalence of coeliac disease (CD) is around 1%, but diagnosis is challenged by varied presentation and non-specific symptoms and signs. This study aimed to identify diagnostic indicators that may help identify patients at a higher risk of CD in whom further testing is warranted.

Methods

International guidance for systematic review methods were followed and the review was registered at PROSPERO (CRD42020170766). Six databases were searched until April 2021. Studies investigating diagnostic indicators, such as symptoms or risk conditions, in people with and without CD were eligible for inclusion. Risk of bias was assessed using the QUADAS-2 tool. Summary sensitivity, specificity, and positive predictive values were estimated for each diagnostic indicator by fit

SUBMITTER: Elwenspoek MMC 

PROVIDER: S-EPMC8545431 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature