Very late vasomotor responses and gene expression with bioresorbable scaffolds and metallic drug-eluting stents.

ABSTRACT:

Objectives

To investigate the long-term vasomotor response and inflammatory changes in Absorb bioresorbable vascular scaffold (BVS) and metallic drug-eluting stent (DES) implanted artery.

Background

Clinical evidence has demonstrated that compared to DES, BVS is associated with higher rates of target lesion failure. However, it is not known whether the higher event rates observed with BVS are related to endothelial dysfunction or inflammation associated with polymer degradation.

Methods

Ten Absorb BVS and six Xience V DES were randomly implanted in the main coronaries of six nonatherosclerotic swine. At 4-years, vasomotor response was evaluated in vivo by quantitative coronary angiography response to intracoronary infusion of Ach and ex vivo by the biomechanical respo

SUBMITTER: Koh JS 

PROVIDER: S-EPMC8545466 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature