Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease: A Secondary Analysis of a Randomized Trial.

ABSTRACT:

Background

The public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is unclear.

Objective

To examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contrast its apparent beneficial and adverse effects.

Design

Subgroup analyses of SPRINT (Systolic Blood Pressure Intervention Trial). (ClinicalTrials.gov: NCT01206062).

Setting

Adults with high blood pressure and elevated cardiovascular risk.

Participants

6662 participants with a baseline estimated glomerular filtration rate (eGFR) of at least 60 mL/min/1.73 m2.

Intervention

Random assignment to an intensive or standard SBP goal (120 or 140 mm Hg, respectively).

Measurements

SUBMITTER: Beddhu S 

PROVIDER: S-EPMC8545525 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature