Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis.

ABSTRACT: Proteasome inhibition with bortezomib has been reported to exert an immunomodulatory action in chronic autoimmune neuropathies. However, bortezomib used for the treatment of multiple myeloma induces a painful toxic polyneuropathy at a higher concentration. Therefore, we addressed this controversial effect and evaluated the neurotoxic and immunomodulatory mode of action of bortezomib in experimental autoimmune neuritis. Bortezomib-induced neuropathy was investigated in Lewis rats using the von Frey hair test, electrophysiological, qPCR and histological analyses of the sciatic nerve as well as dorsal root ganglia outgrowth studies. The immunomodulatory potential of bortezomib was characterized in Lewis rats after experimental autoimmune neuritis induction with P2_53-78 peptide. Cli

SUBMITTER: Klimas R 

PROVIDER: S-EPMC8545613 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature