<i>SCFD1</i> expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed.

ABSTRACT: Evidence indicates that common variants found in genome-wide association studies increase risk of disease through gene regulation via expression Quantitative Trait Loci. Using multiple genome-wide methods, we examined if Single Nucleotide Polymorphisms increase risk of Amyotrophic Lateral Sclerosis through expression Quantitative Trait Loci, and whether expression Quantitative Trait Loci expression is consistent across people who had Amyotrophic Lateral Sclerosis and those who did not. In combining public expression Quantitative Trait Loci data with Amyotrophic Lateral Sclerosis genome-wide association studies, we used Summary-data-based Mendelian Randomization to confirm that SCFD1 was the only gene that was genome-wide significant in mediating Amyotrophic Lateral Sclerosis risk vi

SUBMITTER: Iacoangeli A 

PROVIDER: S-EPMC8545614 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature