¹⁸F-FET-PET-guided gross total resection improves overall survival in patients with WHO grade III/IV glioma: moving towards a multimodal imaging-guided resection.

ABSTRACT:

Purpose

PET using radiolabeled amino acid [¹⁸F]-fluoro-ethyl-_L-tyrosine (FET-PET) is a well-established imaging modality for glioma diagnostics. The biological tumor volume (BTV) as depicted by FET-PET often differs in volume and location from tumor volume of contrast enhancement (CE) in MRI. Our aim was to investigate whether a gross total resection of BTVs defined as < 1 cm³ of residual BTV (PET GTR) correlates with better oncological outcome.

Methods

We retrospectively analyzed imaging and survival data from patients with primary and recurrent WHO grade III or IV gliomas who underwent FET-PET before surgical resection. Tumor overlap between FET-PET and CE was evaluated. Completeness of FET-PET resection (PET GTR) was calculated after super

SUBMITTER: Ort J 

PROVIDER: S-EPMC8545732 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature