Pneumatic Vitreolysis with Perfluoropropane for Vitreomacular Traction with and without Macular Hole: DRCR Retina Network Protocols AG and AH.

ABSTRACT:

Purpose

To evaluate pneumatic vitreolysis (PVL) in eyes with vitreomacular traction (VMT) with and without full-thickness macular hole (FTMH).

Design

Two multicenter (28 sites) studies: a randomized clinical trial comparing PVL with observation (sham injection) for VMT without FTMH (Protocol AG) and a single-arm study assessing PVL for FTMH (Protocol AH).

Participants

Participants were adults with central VMT (vitreomacular adhesion was ≤3000 μm). In Protocol AG, visual acuity (VA) was 20/32 to 20/400. In Protocol AH, eyes had a FTMH (≤250 μm at the narrowest point) and VA of 20/25 to 20/400.

Methods

Pneumatic vitreolysis using perfluoropropane (C₃F₈) gas.

Main outcome measures

Central VMT release at 24 weeks (Protocol AG) and FTMH

SUBMITTER: Chan CK 

PROVIDER: S-EPMC8545749 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature