Maternal active asthma in pregnancy influences associations between polyunsaturated fatty acid intake and child asthma.

ABSTRACT:

Background

Studies evaluating effects of prenatal polyunsaturated fatty acid (PUFA) intake on childhood asthma reveal mixed results. Inconsistencies may result from not accounting for important modifying factors such as maternal asthma or child sex.

Objective

To evaluate whether associations between prenatal PUFA intake and childhood asthma are modified by prenatal active maternal asthma or child sex in 412 mother-child dyads.

Methods

Energy-adjusted prenatal dietary and supplement intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs were estimated using the Block98 Food Frequency Questionnaire, administered during pregnancy. Mothers reported asthma in children followed prospectively to 4.0 plus or minus 1.7 years. Generalized additive models with smooth terms for PUFA (n

SUBMITTER: Flom JD 

PROVIDER: S-EPMC8545828 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature