CCL2 (C-C Motif Chemokine Ligand 2) Biomarker Responses in Central Versus Peripheral Compartments After Focal Cerebral Ischemia.

ABSTRACT:

Background and purpose

Inflammatory mediators in blood have been proposed as potential biomarkers in stroke. However, a direct relationship between these circulating factors and brain-specific ischemic injury remains to be fully defined.

Methods

An unbiased screen in a nonhuman primate model of stroke was used to find out the most responsive circulating biomarker flowing ischemic stroke. Then this phenomenon was checked in human beings and mice. Finally, we observed the temporospatial responsive characteristics of this biomarker after ischemic brain injury in mice to evaluate the direct relationship between this circulating factor and central nervous system–specific ischemic injury.

Results

In a nonhuman primate model, an unbiased screen revealed CCL2 (C-C motif chemo

SUBMITTER: Shi J 

PROVIDER: S-EPMC8545911 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature