Seizure burden in preterm infants and smaller brain volume at term-equivalent age.

ABSTRACT:

Background

Seizures are underrecognized in preterm infants, and little is known about their impact on brain growth. We aimed to define the association between early seizures and subsequent brain growth.

Methods

Infants <30 weeks gestation underwent 72 h of prospective amplitude-integrated electroencephalography (aEEG) monitoring, term-equivalent age (TEA) magnetic resonance imaging (MRI), and 2-year neurodevelopmental testing. Seizures were defined as trains of sharp waves >10 s, evolving in frequency/amplitude/morphology, and identified using automated algorithms with manual review. Using T2-weighted images, cortical surface area (CSA) and gyrification index (GI) were calculated and volumes were segmented into five tissue classes: cerebrospinal fluid, gray matter, white mat

SUBMITTER: Vesoulis ZA 

PROVIDER: S-EPMC8546006 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature