An integrated approach to identify environmental modulators of genetic risk factors for complex traits.

ABSTRACT: Complex traits and diseases can be influenced by both genetics and environment. However, given the large number of environmental stimuli and power challenges for gene-by-environment testing, it remains a critical challenge to identify and prioritize specific disease-relevant environmental exposures. We propose a framework for leveraging signals from transcriptional responses to environmental perturbations to identify disease-relevant perturbations that can modulate genetic risk for complex traits and inform the functions of genetic variants associated with complex traits. We perturbed human skeletal-muscle-, fat-, and liver-relevant cell lines with 21 perturbations affecting insulin resistance, glucose homeostasis, and metabolic regulation in humans and identified thousands of environmenta

SUBMITTER: Balliu B 

PROVIDER: S-EPMC8546041 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature