[¹⁸F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma.

ABSTRACT: The high glycolytic activity of multiple myeloma (MM) cells is the rationale for use of Positron Emission Tomography (PET) with ¹⁸F-fluorodeoxyglucose ([¹⁸F]FDG) to detect both bone marrow (BM) and extramedullary disease. However, new tracers are actively searched because [¹⁸F]FDG-PET has some limitations and there is a portion of MM patients who are negative. Glutamine (Gln) addiction has been recently described as a typical metabolic feature of MM cells. Yet, the possible exploitation of Gln as a PET tracer in MM has never been assessed so far and is investigated in this study in preclinical models. Firstly, we have synthesized enantiopure (2S,4R)-4-fluoroglutamine (4-FGln) and validated it as a Gln transport analogue in human MM cell lines,

SUBMITTER: Valtorta S 

PROVIDER: S-EPMC8546185 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature