Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort.

ABSTRACT:

Background

Attenuation of transforming growth factor β by blocking angiotensin II has been shown to reduce emphysema in a murine model. General population studies have demonstrated that the use of angiotensin converting enzyme inhibitors (ACEis) and angiotensin-receptor blockers (ARBs) is associated with reduction of emphysema progression in former smokers and that the use of ACEis is associated with reduction of FEV₁ progression in current smokers.

Research question

Is use of ACEi and ARB associated with less progression of emphysema and FEV₁ decline among individuals with COPD or baseline emphysema?

Methods

Former and current smokers from the Genetic Epidemiology of COPD Study who attended baseline and 5-year follow-up visits, did not change sm

SUBMITTER: Tejwani V 

PROVIDER: S-EPMC8546238 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature